Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation
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چکیده
منابع مشابه
Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation.
Tumor necrosis factor-α (TNF-α) stimulates osteoclast differentiation and suppresses osteoblast differentiation, leading to bone loss and decreased bone mass in local inflammation areas in patients with rheumatoid arthritis. The growth factor progranulin (PGRN) is expressed in various types of cells and play crucial roles in the pathogenesis of atherosclerosis and arthritis by blocking TNF-α. H...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2016
ISSN: 1676-5680
DOI: 10.4238/gmr.15038126